Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 18/20 | 0.61 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.53 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.53 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL898201 | 0.87 | ALK (0.76) | ALKSRPK1SRPK2EML4 | |
| SCHEMBL897656 | 0.86 | ALK (0.60) | ALKSRPK1SRPK2 | |
| SCHEMBL7801516 | 0.84 | ALK (0.64) | ALK | |
| SCHEMBL21613393 | 0.84 | ALK (0.68) | ALK | |
| SCHEMBL897360 | 0.81 | ALK (0.65) | ALKSRPK1SRPK2EML4 | |
| SCHEMBL16775671 | 0.78 | ALK (0.78) | ALKSRPK1SRPK2EML4 | |
| SCHEMBL897185 | 0.78 | ALK (0.79) | ALKSRPK1SRPK2EML4 | |
| SCHEMBL897528 | 0.78 | ALK (0.92) | ALKSRPK1SRPK2EML4 | |
| SCHEMBL10283126 | 0.78 | ALK (0.78) | ALKSRPK1SRPK2EML4 | |
| SCHEMBL897356 | 0.78 | ALK (0.70) | ALKSRPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613729-A1 | TETRACYCLIC COMPOUNDS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2020-02-26 | — | — | EP | disclosed |
| EP-2606886-B1 | COMPOSITION COMPRISING TETRACYCLIC COMPOUND | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2020-01-08 | — | — | EP | disclosed |
| EP-3345903-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2019-10-09 | — | — | EP | disclosed |
| EP-3345903-A1 | TETRACYCLIC COMPOUNDS | Chugai Seiyaku Kabushiki Kaisha (JP) | 2018-07-11 | — | — | EP | disclosed |