Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.73 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25446834 | 0.90 | ALK (0.61) | ALKKITKDR | |
| SCHEMBL25446835 | 0.89 | ALK (0.58) | ALK | |
| SCHEMBL20366593 | 0.89 | ALK (0.58) | ALK | |
| SCHEMBL25446842 | 0.87 | ALK (0.61) | ALKKITKDR | |
| SCHEMBL20004748 | 0.87 | ALK (0.82) | ALKKITKDR | |
| SCHEMBL20366569 | 0.87 | ALK (0.59) | ALKKITKDR | |
| SCHEMBL24675726 | 0.85 | ALK (0.76) | ALKKDR | |
| SCHEMBL897169 | 0.85 | ALK (1.00) | ALKKITKDR | |
| SCHEMBL21443222 | 0.81 | ALK (0.48) | ALK | |
| SCHEMBL20004266 | 0.79 | ALK (0.61) | ALKKITKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613729-A1 | TETRACYCLIC COMPOUNDS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2020-02-26 | — | — | EP | disclosed |
| EP-3345903-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2019-10-09 | — | — | EP | disclosed |
| EP-3345903-A1 | TETRACYCLIC COMPOUNDS | Chugai Seiyaku Kabushiki Kaisha (JP) | 2018-07-11 | — | — | EP | disclosed |