Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.72 |
| ▸ | JAK3 | P52333 | 8/20 | 0.72 |
| ▸ | JAK1 | P23458 | 6/20 | 0.70 |
| ▸ | BTK | Q06187 | 5/20 | 0.70 |
| ▸ | TYK2 | P29597 | 1/20 | 0.70 |
| ▸ | EGFR | P00533 | 4/20 | 0.70 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.69 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.65 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.65 |
| ▸ | KDR | P35968 | 2/20 | 0.65 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18619685 | 1.00 | JAK2 (0.72) | JAK2JAK3JAK1BTKTYK2 | |
| SCHEMBL18618502 | 0.94 | EGFR (0.80) | JAK2JAK3JAK1BTKTYK2 | |
| SCHEMBL18598903 | 0.94 | EGFR (0.80) | JAK2JAK3JAK1BTKTYK2 | |
| SCHEMBL26414383 | 0.94 | EGFR (0.80) | JAK2JAK3JAK1BTKTYK2 | |
| SCHEMBL17911486 | 0.88 | EGFR (0.88) | JAK2JAK3JAK1BTKTYK2 | |
| SCHEMBL30082483 | 0.88 | EGFR (0.88) | JAK2JAK3JAK1BTKTYK2 | |
| SCHEMBL17235861 | 0.88 | EGFR (0.88) | JAK2JAK3JAK1BTKTYK2 | |
| SCHEMBL17267791 | 0.88 | EGFR (0.88) | JAK2JAK3JAK1BTKTYK2 | |
| SCHEMBL19194158 | 0.88 | FGFR2 (0.67) | JAK2JAK3JAK1BTKTYK2 | |
| SCHEMBL18619684 | 0.88 | JAK2 (0.66) | JAK2JAK3JAK1BTKTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3345907-B1 | PYRAZOLO[3,4-D]PYRIMIDINE COMPOUNDS OR SALTS THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2020-04-22 | — | — | EP | disclosed |
| EP-3345907-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUND OR SALT THEREOF | Taiho Pharmaceutical Co., Ltd. (JP) | 2018-07-11 | — | — | EP | disclosed |