Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.34 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.34 |
| ▸ | ESYT2 | A0FGR8 | 2/20 | 0.34 |
| ▸ | NBAS | A2RRP1 | 2/20 | 0.34 |
| ▸ | CNOT1 | A5YKK6 | 2/20 | 0.34 |
| ▸ | TBKBP1 | A7MCY6 | 2/20 | 0.34 |
| ▸ | AGPS | O00116 | 2/20 | 0.34 |
| ▸ | MYO1F | O00160 | 2/20 | 0.34 |
| ▸ | SNAP23 | O00161 | 2/20 | 0.34 |
| ▸ | AP3B1 | O00203 | 2/20 | 0.34 |
| ▸ | PSMD12 | O00232 | 2/20 | 0.34 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.34 |
| ▸ | PGRMC1 | O00264 | 2/20 | 0.34 |
| ▸ | CLIC1 | O00299 | 2/20 | 0.34 |
| ▸ | CDC7 | O00311 | 2/20 | 0.34 |
| ▸ | IPO5 | O00410 | 2/20 | 0.34 |
| ▸ | PLK4 | O00444 | 2/20 | 0.34 |
| ▸ | COXFA4 | O00483 | 2/20 | 0.34 |
| ▸ | NOP56 | O00567 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20376697 | 0.95 | MAPK14 (0.61) | MAPK14DDR2ABL1BTKPIKFYVE | |
| SCHEMBL20376698 | 0.94 | MAPK14 (0.62) | MAPK14DDR2LYNBRAFEPHB4 | |
| SCHEMBL15946946 | 0.75 | MAPK14 (1.00) | MAPK14YES1PKMBRAFRAF1 | |
| SCHEMBL20357846 | 0.72 | MAPK14 (0.60) | MAPK14BRAFPIKFYVE | |
| SCHEMBL14691518 | 0.71 | MAPK14 (0.60) | MAPK14LMNABRAFMAPK1ALDH1A1 | |
| SCHEMBL30879828 | 0.71 | MAPK14 (0.59) | MAPK14LCKBTKCDK2KDR | |
| SCHEMBL14691348 | 0.71 | MAPK14 (0.59) | MAPK14LCKBTKCDK2KDR | |
| SCHEMBL14691347 | 0.71 | MAPK14 (0.58) | MAPK14LCKBRAFBTKKDR | |
| SCHEMBL15946947 | 0.70 | MAPK14 (1.00) | MAPK14YES1BRAFRAF1PIKFYVE | |
| SCHEMBL30879818 | 0.70 | MAPK14 (0.58) | MAPK14BRAFPIKFYVE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2739143-B1 | PREPARATION AND METHODS OF USE FOR ORTHO-ARYL 5- MEMBERED HETEROARYL-CARBOXAMIDE CONTAINING MULTI-TARGETED KINASE INHIBITORS | FLYNN GARY A (US) | 2018-07-11 | — | — | EP | disclosed |