SCHEMBL20376705

SCHEMBL20376705

CC(C)(C=O)C1CCN(c2ccc(Nc3nc(-c4ccccc4)nc4cn[nH]c(=O)c34)cc2)CC1

nearest known ligand 0.79

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SYK P43405 19/20 0.79
JAK2 O60674 12/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14717857 0.89 SYK (1.00) SYKJAK2
SCHEMBL14717039 0.88 SYK (0.78) SYKJAK2
SCHEMBL20376651 0.85 SYK (0.82) SYKJAK2
SCHEMBL20376360 0.85 SYK (0.82) SYKJAK2
SCHEMBL14716844 0.84 SYK (1.00) SYKJAK2
SCHEMBL14717067 0.83 SYK (1.00) SYKJAK2
SCHEMBL30604878 0.83 SYK (0.84) SYKJAK2
SCHEMBL29635050 0.82 SYK (0.82) SYKJAK2
SCHEMBL20357874 0.82 SYK (0.82) SYKJAK2
SCHEMBL14717038 0.82 SYK (1.00) SYKJAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2748166-B1 PYRIMIDO-PYRIDAZINONE COMPOUNDS AND USE THEREOF ASANA BIOSCIENCES LLC (US) 2018-07-11 EP disclosed