Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 5/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
| ▸ | TYK2 | P29597 | 3/20 | 0.35 |
| ▸ | KHK | P50053 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18592814 | 1.00 | LRRK2 (0.39) | LRRK2PIM1MAP4K1JAK2TYK2 | |
| SCHEMBL18592872 | 0.91 | KHK (0.41) | LRRK2PIM1JAK2TYK2KHK | |
| SCHEMBL18592869 | 0.91 | KHK (0.41) | LRRK2PIM1JAK2TYK2KHK | |
| SCHEMBL18592873 | 0.91 | KHK (0.41) | LRRK2PIM1JAK2TYK2KHK | |
| SCHEMBL18593005 | 0.81 | LRRK2 (0.31) | LRRK2JAK2TYK2KHK | |
| SCHEMBL18593004 | 0.81 | LRRK2 (0.31) | LRRK2JAK2TYK2KHK | |
| SCHEMBL18592840 | 0.78 | JAK2 (0.38) | LRRK2JAK2TYK2ALDH1A1CYP2D6 | |
| SCHEMBL18592978 | 0.78 | JAK2 (0.39) | LRRK2JAK2TYK2ALDH1A1CYP2D6 | |
| SCHEMBL18592837 | 0.78 | JAK2 (0.38) | LRRK2JAK2TYK2ALDH1A1CYP2D6 | |
| SCHEMBL18592838 | 0.78 | JAK2 (0.38) | LRRK2JAK2TYK2ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10023571-B2 | TYK2 inhibitors and uses thereof | Nimbus Lakshimi, Inc. (US) | 2018-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023571-B2 | TYK2 inhibitors and uses thereof | TYK2, JAK1, JAK2 | LRRK2 259/4885PIM1 260/4885MAP4K1 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.