SCHEMBL20384666

SCHEMBL20384666

C=CC(=O)N1CC(OCCn2c(=O)c(-c3c(Cl)c(OC)cc(OC)c3Cl)cc3cnc(NC4CCCCC4)nc32)C1

nearest known ligand 0.90

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 20/20 0.90
FGFR2 P21802 9/20 0.90

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16997109 0.94 FGFR1 (1.00) FGFR1FGFR2
SCHEMBL17910163 0.94 FGFR1 (1.00) FGFR1FGFR2
SCHEMBL16993163 0.94 FGFR1 (1.00) FGFR1FGFR2
SCHEMBL16993121 0.91 FGFR1 (1.00) FGFR1FGFR2
SCHEMBL16993174 0.89 FGFR1 (0.89) FGFR1FGFR2
SCHEMBL16997103 0.89 FGFR1 (1.00) FGFR1FGFR2
SCHEMBL30850770 0.89 FGFR1 (1.00) FGFR1FGFR2
SCHEMBL16993141 0.88 FGFR1 (1.00) FGFR1FGFR2
SCHEMBL16992995 0.87 FGFR1 (1.00) FGFR1FGFR2
SCHEMBL16992996 0.87 FGFR1 (1.00) FGFR1FGFR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3102577-B1 QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS PRINCIPIA BIOPHARMA INC (US) 2018-07-18 EP disclosed