Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20385796 | 1.00 | TAAR1 (0.46) | TAAR1SLC6A4KDM1ACYP2D6NPC1 | |
| SCHEMBL11191703 | 0.81 | KDM1A (0.45) | TAAR1SLC6A4KDM1ANPC1MAPT | |
| SCHEMBL3610206 | 0.81 | TAAR1 (0.62) | TAAR1CYP2D6 | |
| SCHEMBL3610201 | 0.81 | TAAR1 (0.62) | TAAR1CYP2D6 | |
| SCHEMBL23771879 | 0.80 | SLC6A4 (0.46) | TAAR1SLC6A4KDM1ANPC1MAPT | |
| SCHEMBL20289407 | 0.80 | NPC1 (0.45) | TAAR1SLC6A4KDM1ACYP2D6NPC1 | |
| SCHEMBL20286123 | 0.80 | SLC6A4 (0.42) | TAAR1SLC6A4KDM1ACYP2D6NPC1 | |
| SCHEMBL20289042 | 0.80 | NPC1 (0.45) | TAAR1SLC6A4KDM1ACYP2D6NPC1 | |
| SCHEMBL20286137 | 0.80 | SLC6A4 (0.42) | TAAR1SLC6A4KDM1ACYP2D6NPC1 | |
| SCHEMBL29999888 | 0.80 | SLC6A4 (0.42) | TAAR1SLC6A4KDM1ACYP2D6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3555100-B1 | BENZODIAZEPINE DERIVATIVES, COMPOSITIONS, AND METHODS FOR TREATING COGNITIVE IMPAIRMENT | AGENEBIO INC (US) | 2023-05-10 | — | — | EP | disclosed |
| WO-2018130868-A1 | BENZODIAZEPINE DERIVATIVES, COMPOSITIONS, AND METHODS FOR TREATING COGNITIVE IMPAIRMENT | AGENEBIO, INC. (US) | 2018-07-19 | — | — | WO | disclosed |
| WO-2018130869-A1 | BENZODIAZEPINE DERIVATIVES, COMPOSITIONS, AND METHODS FOR TREATING COGNITIVE IMPAIRMENT | AGENEBIO, INC. (US) | 2018-07-19 | — | — | WO | disclosed |