Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Naproxen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 4/20 | 0.72 |
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 0.72 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.72 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.72 |
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.72 |
| ▸ | CDC42 | P60953 | 1/20 | 0.72 |
| ▸ | RAC1 | P63000 | 1/20 | 0.72 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naproxen SCHEMBL27586482 | 1.00 | AKR1C3 (0.72) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL2487827 | 0.89 | AKR1C3 (0.57) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL23753934 | 0.85 | AKR1C3 (0.88) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL28881206 | 0.85 | AKR1C3 (0.88) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL30346195 | 0.85 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL3046 | 0.85 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL29350704 | 0.85 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL10029028 | 0.85 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL215236 | 0.85 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL42434 | 0.85 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200245646-A1 | THERAPEUTIC COMPOSITION INCLUDING CARBONATED SOLUTION | VISION PHARMA, LLC | 2020-08-06 | — | — | US | claimed |
| EP-4046491-A1 | INSECT REPELLENT | FMC Corporation (US) | 2022-08-24 | — | — | EP | disclosed |
| US-20200163334-A1 | INSECT REPELLENT | LINTZ, DONNA | 2020-05-28 | — | — | US | disclosed |
| EP-3422853-A1 | INSECT REPELLENT | FMC Corporation (US) | 2019-01-09 | — | — | EP | disclosed |
| US-10149470-B2 | Methods and compositions for vein harvest and autografting | VANDERBILT UNIVERSITY (US) | 2018-12-11 | — | — | US | disclosed |
| EP-2848256-B1 | Improved methods and compositions for vein harvest and autografting | UNIV VANDERBILT (US) | 2018-11-14 | — | — | EP | disclosed |
| CN-104623665-B | For venous collection and the improved method and composition of autotransplantation | 范德比尔特大学 | 2018-01-12 | — | — | CN | disclosed |
| US-20170071192-A1 | METHODS AND COMPOSITIONS FOR VEIN HARVEST AND AUTOGRAFTING | VANDERBILT UNIVERSITY | 2017-03-16 | — | — | US | disclosed |
| CN-104623665-A | Improved methods and compositions for vein harvest and autografting | UNIV VANDERBILT | 2015-05-20 | — | — | CN | disclosed |
| EP-2848256-A2 | Improved methods and compositions for vein harvest and autografting | Vanderbilt University (US) | 2015-03-18 | — | — | EP | disclosed |
| CN-102834102-B | Improved methods and compositions for vein harvesting and autografting | UNIV VANDERBILT | 2015-01-14 | — | — | CN | disclosed |
| EP-2509609-B1 | IMPROVED METHODS AND COMPOSITIONS FOR VEIN HARVEST AND AUTOGRAFTING | UNIV VANDERBILT (US) | 2014-10-01 | — | — | EP | disclosed |
| US-20140220547-A1 | Methods and Compositions for Vein Harvest and Autografting | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (US) | 2014-08-07 | — | — | US | disclosed |
| CN-102834102-A | Improved methods and compositions for vein harvesting and autografting | UNIV VANDERBILT | 2012-12-19 | — | — | CN | disclosed |
| EP-2509609-A2 | IMPROVED METHODS AND COMPOSITIONS FOR VEIN HARVEST AND AUTOGRAFTING | Vanderbilt University (US) | 2012-10-17 | — | — | EP | disclosed |
| US-20110190572-A1 | Methods and Compositions for Vein Harvest and Autografting | VANDERBILT UNIVERSITY | 2011-08-04 | — | — | US | disclosed |
| WO-2011072012-A2 | IMPROVED METHODS AND COMPOSITIONS FOR VEIN HARVEST AND AUTOGRAFTING | VANDERBILT UNIVERSITY (US) | 2011-06-16 | — | — | WO | disclosed |