Sugi Predict

Sugi Predict / Compounds / SCHEMBL20386908

SCHEMBL20386908

SCHEMBL20386908

C[Si](C)(O)CCCNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GSK3B P49841 2/20 0.80
▸ RAF1 P04049 11/20 0.78
▸ HDAC3 O15379 6/20 0.78
▸ HDAC4 P56524 6/20 0.78
▸ HDAC1 Q13547 6/20 0.78
▸ HDAC7 Q8WUI4 6/20 0.78
▸ HDAC2 Q92769 6/20 0.78
▸ HDAC10 Q969S8 6/20 0.78
▸ HDAC11 Q96DB2 6/20 0.78
▸ HDAC8 Q9BY41 6/20 0.78
▸ HDAC6 Q9UBN7 6/20 0.78
▸ HDAC9 Q9UKV0 6/20 0.78
▸ HDAC5 Q9UQL6 6/20 0.78
▸ KDR P35968 4/20 0.76
▸ PDGFRB P09619 3/20 0.76
▸ ARAF P10398 2/20 0.76
▸ BRAF P15056 2/20 0.76
▸ RET P07949 2/20 0.73
▸ MEN1 O00255 1/20 0.73
▸ PLK4 O00444 1/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20386909 0.95 RAF1 (0.81) GSK3BRAF1HDAC3HDAC4HDAC1
SCHEMBL20909069 0.91 RAF1 (0.82) GSK3BRAF1HDAC3HDAC4HDAC1
SCHEMBL3707691 0.90 RAF1 (0.83) GSK3BRAF1HDAC3HDAC4HDAC1
SCHEMBL21973628 0.89 RAF1 (0.82) GSK3BRAF1HDAC3HDAC4HDAC1
SCHEMBL4340104 0.89 GSK3B (0.85) GSK3BRAF1HDAC3HDAC4HDAC1
SCHEMBL22001800 0.89 RAF1 (0.82) GSK3BRAF1HDAC3HDAC4HDAC1
SCHEMBL20386910 0.89 GSK3B (0.78) GSK3BRAF1HDAC3HDAC4HDAC1
SCHEMBL20383029 0.88 GSK3B (0.62) GSK3BRAF1HDAC3HDAC4HDAC1
SCHEMBL937568 0.88 RAF1 (1.00) GSK3BRAF1HDAC3HDAC4HDAC1
SCHEMBL4342506 0.88 HDAC3 (0.83) GSK3BRAF1HDAC3HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220184104-A1 SILANOL BASED THERAPEUTIC PAYLOADS BLINKBIO INC (US) 2022-06-16 — — US disclosed
US-20210161921-A1 Silanol Based Therapeutic Payloads BLINKBIO, INC. 2021-06-03 — — US disclosed
US-10716801-B2 Silanol based therapeutic payloads BLINKBIO, INC. (US) 2020-07-21 — — US disclosed
US-20190183913-A1 Silanol Based Therapeutic Payloads BLINKBIO INC (US) 2019-06-20 — — US disclosed
US-10293053-B2 Silanol based therapeutic payloads BLINKBIO, INC. (US) 2019-05-21 — — US disclosed
US-20180200273-A1 Silanol Based Therapeutic Payloads BLINKBIO INC (US) 2018-07-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190183913-A1 Silanol Based Therapeutic Payloads CD47, CD4, BST2 GSK3B 4346/4885RAF1 4399/4885HDAC3 822/4885
US-20210161921-A1 Silanol Based Therapeutic Payloads CD47, CD4, BST2 GSK3B 4346/4885RAF1 4399/4885HDAC3 822/4885
US-10716801-B2 Silanol based therapeutic payloads CD47, CD4, BST2 GSK3B 4346/4885RAF1 4399/4885HDAC3 822/4885
US-20180200273-A1 Silanol Based Therapeutic Payloads CD47, CD4, BST2 GSK3B 4346/4885RAF1 4399/4885HDAC3 822/4885
US-10293053-B2 Silanol based therapeutic payloads CD47, CD4, BST2 GSK3B 4346/4885RAF1 4399/4885HDAC3 822/4885
US-20220184104-A1 SILANOL BASED THERAPEUTIC PAYLOADS CD47, CD4, BST2 GSK3B 4346/4885RAF1 4399/4885HDAC3 822/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.