Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 14/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11621060 | 0.85 | HTT (0.76) | NAMPTHTTROCK2ROCK1 | |
| SCHEMBL20389277 | 0.83 | NAMPT (0.63) | NAMPTHTTROCK2ROCK1 | |
| SCHEMBL20389466 | 0.82 | NAMPT (0.58) | NAMPTHTTROCK2ROCK1 | |
| SCHEMBL20389015 | 0.82 | NAMPT (0.65) | NAMPTROCK2 | |
| SCHEMBL20389281 | 0.81 | NAMPT (0.67) | NAMPTHTTROCK2ROCK1 | |
| SCHEMBL20389187 | 0.81 | HTT (0.64) | NAMPTHTTROCK2ROCK1 | |
| SCHEMBL20389188 | 0.80 | NAMPT (0.66) | NAMPTHTTROCK2ROCK1 | |
| SCHEMBL20389213 | 0.78 | NAMPT (0.67) | NAMPTHTTROCK2ROCK1 | |
| SCHEMBL20389223 | 0.78 | NAMPT (0.57) | NAMPTHTTROCK2ROCK1 | |
| SCHEMBL11618393 | 0.78 | NAMPT (1.00) | NAMPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018132372-A1 | SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2018-07-19 | — | — | WO | disclosed |