SCHEMBL2039693

SCHEMBL2039693

FC(F)(F)c1nc[c][nH]1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2047153 0.65
SCHEMBL394747 0.56
SCHEMBL1032038 0.56
SCHEMBL1529216 0.56
SCHEMBL25335684 0.55 CYP19A1 (0.41)
SCHEMBL11256496 0.55 HTT (0.37)
SCHEMBL447337 0.55
SCHEMBL2038975 0.55
SCHEMBL157584 0.54
SCHEMBL2892232 0.54 CSNK2A1 (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1333834-A4 ANTIINFLAMMATION AGENTS AMGEN INC (US) 2007-01-17 EP claimed
EP-1444223-A1 AMINOPYRIMIDINES AND -PYRIDINES F. HOFFMANN-LA ROCHE AG (CH) 2004-08-11 EP claimed
EP-1333834-A2 ANTIINFLAMMATION AGENTS Tularik Inc. (US) 2003-08-13 EP claimed
WO-2003048152-A2 INFLAMMATION MODULATORS TULARIK INC. (US) 2003-06-12 WO claimed
WO-2003040131-A1 AMINOPYRIMIDINES AND PYRIDINES F. HOFFMANN-LA ROCHE AG (CH) 2003-05-15 WO claimed
WO-2002041843-A2 ANTIINFLAMMATION AGENTS TULARIK INC. (US) 2002-05-30 WO claimed
US-20120291159-A1 Azoline Compounds for Combating Invertebrate Pests BASF SE (DE) 2012-11-15 US disclosed
WO-2011073444-A2 AZOLINE COMPOUNDS FOR COMBATING INVERTEBRATE PESTS BASF SE (DE) 2011-06-23 WO disclosed
EP-1333834-A4 ANTIINFLAMMATION AGENTS AMGEN INC (US) 2007-01-17 EP disclosed
US-20060004033-A1 Imidazolo-5-yl-2-anilino-pyrimidines as agents for the inhibition of the cell proliferation ASTRAZENECA AB 2006-01-05 US disclosed
US-6969714-B2 Imidazolo-5-YL-2-anilino-pyrimidines as agents for the inhibition of the cell proliferation ASTRAZENECA AB (SE) 2005-11-29 US disclosed
EP-1444223-A1 AMINOPYRIMIDINES AND -PYRIDINES F. HOFFMANN-LA ROCHE AG (CH) 2004-08-11 EP disclosed
EP-1351958-A1 IMIDAZOLO-5-YL-2-ANILINO-PYRIMIDINES AS AGENTS FOR THE INHIBITION OF THE CELL PROLIFERATION AstraZeneca AB (SE) 2003-10-15 EP disclosed
EP-1333834-A2 ANTIINFLAMMATION AGENTS Tularik Inc. (US) 2003-08-13 EP disclosed
WO-2003040131-A1 AMINOPYRIMIDINES AND PYRIDINES F. HOFFMANN-LA ROCHE AG (CH) 2003-05-15 WO disclosed
WO-2002041843-A2 ANTIINFLAMMATION AGENTS TULARIK INC. (US) 2002-05-30 WO disclosed
WO-2002020512-A1 IMIDAZOLO-5-YL-2-ANILINO-PYRIMIDINES AS AGENTS FOR THE INHIBITION OF THE CELL PROLIFERATION ASTRAZENECA AB (SE) 2002-03-14 WO disclosed