Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1514910 | 1.00 | USP2 (0.47) | USP2SMN1; SMN2HTTATMALDH1A1 | |
| SCHEMBL30405864 | 0.94 | MEN1 (0.45) | USP2SMN1; SMN2HTTATMALDH1A1 | |
| SCHEMBL1505020 | 0.85 | USP2 (0.49) | USP2SMN1; SMN2HTTATMALDH1A1 | |
| SCHEMBL6424563 | 0.84 | SMN1; SMN2 (0.45) | USP2SMN1; SMN2HTTATMALDH1A1 | |
| SCHEMBL24669979 | 0.83 | USP2 (0.50) | USP2SMN1; SMN2HTTATMALDH1A1 | |
| SCHEMBL27365962 | 0.83 | USP2 (0.50) | USP2SMN1; SMN2HTTATMALDH1A1 | |
| SCHEMBL64202 | 0.83 | USP2 (0.50) | USP2SMN1; SMN2HTTATMALDH1A1 | |
| SCHEMBL30184040 | 0.83 | CYP2C9 (0.45) | USP2SMN1; SMN2ALDH1A1EPHX2 | |
| Lithium SCHEMBL31218220 | 0.82 | USP2 (0.49) | USP2SMN1; SMN2HTTATMALDH1A1 | |
| Hydrochloric Acid SCHEMBL2419232 | 0.82 | USP2 (0.49) | USP2SMN1; SMN2HTTATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3601249-A1 | METHODS FOR TREATING HEMATOLOGICAL MALIGNANCIES AND EWING'S SARCOMA | Kura Oncology, Inc. (US) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018175746-A1 | METHODS FOR TREATING HEMATOLOGICAL MALIGNANCIES AND EWING'S SARCOMA | KURA ONCOLOGY, INC. (US) | 2018-09-27 | — | — | WO | disclosed |
| WO-2018134213-A1 | JAK1 SELECTIVE INHIBITORS | ASTRAZENECA AB (SE) | 2018-07-26 | — | — | WO | disclosed |