Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.87 |
| ▸ | JAK1 | P23458 | 15/20 | 0.87 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30018063 | 0.93 | JAK2 (1.00) | JAK2JAK1 | |
| SCHEMBL20399299 | 0.93 | JAK2 (1.00) | JAK2JAK1 | |
| SCHEMBL30018468 | 0.93 | JAK2 (1.00) | JAK2JAK1 | |
| SCHEMBL20399316 | 0.93 | JAK2 (1.00) | JAK2JAK1 | |
| SCHEMBL20399297 | 0.93 | JAK2 (1.00) | JAK2JAK1 | |
| SCHEMBL20399301 | 0.92 | JAK2 (1.00) | JAK2JAK1 | |
| SCHEMBL30018256 | 0.92 | JAK2 (1.00) | JAK2JAK1 | |
| SCHEMBL20399390 | 0.92 | JAK2 (1.00) | JAK2JAK1 | |
| SCHEMBL20399300 | 0.92 | JAK2 (1.00) | JAK2JAK1 | |
| SCHEMBL30018522 | 0.92 | JAK2 (1.00) | JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018134213-A1 | JAK1 SELECTIVE INHIBITORS | ASTRAZENECA AB (SE) | 2018-07-26 | — | — | WO | disclosed |