Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.31 |
| ▸ | ACE | P12821 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18628568 | 0.85 | BTK (0.47) | BTKANPEPTSHRSLC6A1LMNA | |
| SCHEMBL14436576 | 0.82 | BTK (0.49) | BTKANPEPTSHRSLC6A1LMNA | |
| SCHEMBL20047617 | 0.82 | BTK (0.49) | BTKANPEPTSHRSLC6A1LMNA | |
| SCHEMBL863425 | 0.82 | BTK (0.49) | BTKANPEPTSHRSLC6A1LMNA | |
| SCHEMBL17895800 | 0.75 | BTK (0.50) | BTKANPEPTSHRSLC6A1LMNA | |
| SCHEMBL25250387 | 0.75 | BTK (0.41) | BTKANPEPTSHRSLC6A1LMNA | |
| SCHEMBL849602 | 0.75 | BTK (0.41) | BTKANPEPTSHRSLC6A1LMNA | |
| SCHEMBL26620727 | 0.75 | BTK (0.41) | BTKANPEPTSHRSLC6A1LMNA | |
| SCHEMBL20643397 | 0.74 | BTK (0.42) | BTKSMN1; SMN2EPHX2ALDH1A1 | |
| SCHEMBL4020947 | 0.74 | BTK (0.45) | BTKANPEPTSHRSLC6A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3427738-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | Vertex Pharmaceuticals Incorporated (US) | 2019-01-16 | — | — | EP | disclosed |
| EP-3141252-B1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMA (US) | 2018-07-25 | — | — | EP | disclosed |