SCHEMBL20405

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL21537	0.86	TTK (0.43)	JAK2TTKJAK3PTK2
	SCHEMBL20247	0.82	FLT1 (0.41)	JAK2JAK3PTK2KDRFLT1
	SCHEMBL21042	0.80	JAK2 (0.43)	JAK2TTKJAK3PTK2NUAK1
	SCHEMBL21985	0.78	JAK2 (0.41)	JAK2TTKJAK3PTK2PDE6D
	SCHEMBL15210398	0.78	JAK2 (0.50)	JAK2JAK3PTK2PDE6APDE10A
	SCHEMBL15210525	0.76	SYK (0.45)	JAK2JAK3PTK2MAPK14KDR
	SCHEMBL20918	0.73	FLT1 (0.42)	JAK2JAK3PTK2FGFR1KDR
	SCHEMBL21584	0.72	FLT1 (0.44)	JAK2JAK3PTK2KDRFLT1
	SCHEMBL15210501	0.72	JAK2 (0.41)	JAK2JAK3PTK2NUAK1KDR
	SCHEMBL19502	0.72	JAK2 (0.41)	JAK2JAK3PTK2NUAK1KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.