Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.33 |
| ▸ | GPR6 | P46095 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18661468 | 0.89 | SYK (0.39) | MAPTKDM4EMAPK1NPSR1POLB | |
| SCHEMBL20394406 | 0.85 | GPBAR1 (0.39) | MAPTKDM4EMAPK1NPSR1POLB | |
| SCHEMBL20394367 | 0.85 | SYK (0.38) | MAPTKDM4EMAPK1NPSR1POLB | |
| SCHEMBL20755025 | 0.85 | KDM4E (0.41) | MAPTKDM4EMAPK1NPSR1POLB | |
| SCHEMBL18661455 | 0.85 | PDE10A (0.43) | PDE10A | |
| SCHEMBL18661469 | 0.84 | SYK (0.39) | MAPTKDM4EMAPK1NPSR1POLB | |
| SCHEMBL20406717 | 0.83 | SYK (0.37) | MAPTKDM4EMAPK1NPSR1POLB | |
| SCHEMBL20406480 | 0.81 | SYK (0.37) | MAPTKDM4EMAPK1NPSR1POLB | |
| SCHEMBL20394474 | 0.81 | SYK (0.41) | MAPTKDM4EMAPK1NPSR1POLB | |
| SCHEMBL20406778 | 0.80 | ABL1 (0.35) | PDE10AGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3351533-A1 | BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME | Kaken Pharmaceutical Co., Ltd. (JP) | 2018-07-25 | — | — | EP | disclosed |