Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.36 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.35 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.35 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.35 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20406690 | 0.86 | PDE10A (0.38) | LIPEPDE10APLAAT3PLAAT5PLAAT2 | |
| SCHEMBL20406391 | 0.83 | MEN1 (0.46) | LIPEPDE10APLAAT3PLAAT5PLAAT2 | |
| SCHEMBL18661502 | 0.83 | PDE10A (0.39) | LIPEPDE10APLAAT3PLAAT5PLAAT2 | |
| SCHEMBL20394338 | 0.83 | PDE5A (0.43) | PDE10AGPBAR1ALOX5APFEN1CHRNB2 | |
| SCHEMBL20394318 | 0.81 | PDE10A (0.38) | LIPEPDE10APLAAT3PLAAT5PLAAT2 | |
| SCHEMBL20394417 | 0.80 | ALOX5AP (0.43) | PDE10AALOX5APFEN1SCN9A | |
| SCHEMBL20394463 | 0.79 | PDE10A (0.38) | PDE10APLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL20394274 | 0.79 | PDE5A (0.39) | PDE10AGPBAR1ALOX5APFEN1CHRNB2 | |
| SCHEMBL20394435 | 0.78 | FEN1 (0.40) | PDE10AFEN1 | |
| SCHEMBL20394456 | 0.77 | GRM5 (0.39) | PDE10AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3351533-A1 | BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME | Kaken Pharmaceutical Co., Ltd. (JP) | 2018-07-25 | — | — | EP | disclosed |