Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.39 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20394430 | 0.92 | PDE10A (0.44) | PDE10AGPBAR1P2RY1 | |
| SCHEMBL20394508 | 0.92 | PDE10A (0.44) | PDE10AGPBAR1P2RY1ALDH1A1GAA | |
| SCHEMBL20394266 | 0.88 | PDE10A (0.41) | PDE10AGPBAR1P2RY1ALDH1A1 | |
| SCHEMBL20394277 | 0.86 | PDE10A (0.40) | PDE10AGPBAR1ALDH1A1 | |
| SCHEMBL20394425 | 0.85 | PDE10A (0.40) | PDE10AGPBAR1 | |
| SCHEMBL20394448 | 0.83 | PDE10A (0.45) | PDE10AALDH1A1MAPT | |
| SCHEMBL20406787 | 0.83 | PDE10A (0.39) | PDE10AGPBAR1 | |
| SCHEMBL20394510 | 0.82 | PDE10A (0.43) | PDE10AALDH1A1GAAMAPTABL1 | |
| SCHEMBL20394197 | 0.82 | PDE10A (0.41) | PDE10AALDH1A1 | |
| SCHEMBL18661455 | 0.81 | PDE10A (0.43) | PDE10AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10647675-B2 | Biaryl derivative and medicine containing same | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2020-05-12 | — | — | US | disclosed |
| US-20190055199-A1 | BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2019-02-21 | — | — | US | disclosed |
| EP-3351533-A1 | BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME | Kaken Pharmaceutical Co., Ltd. (JP) | 2018-07-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10647675-B2 | Biaryl derivative and medicine containing same | MAN2B1, CBR3, MANBA | PDE10A 4605/4885GPBAR1 2116/4885P2RY1 2487/4885 |
| US-20190055199-A1 | BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME | MAN2B1, CBR3, MANBA | PDE10A 4605/4885GPBAR1 2116/4885P2RY1 2487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.