Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 17/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1962013 | 0.84 | GCK (0.75) | GCK | |
| SCHEMBL1960871 | 0.83 | GCK (0.61) | GCK | |
| SCHEMBL2199152 | 0.83 | GCK (0.73) | GCK | |
| SCHEMBL1958744 | 0.82 | GCK (0.60) | GCKPTGS2PTGS1 | |
| Hydrochloric Acid SCHEMBL1962614 | 0.82 | GCK (0.60) | GCKMAPK8MAPK9MAPK10PTGS2 | |
| SCHEMBL1960910 | 0.82 | GCK (0.65) | GCK | |
| SCHEMBL1958746 | 0.82 | GCK (0.60) | GCKPTGS2PTGS1 | |
| SCHEMBL1960967 | 0.82 | GCK (0.57) | GCKMAPK8MAPK9MAPK10 | |
| SCHEMBL1960966 | 0.82 | GCK (0.57) | GCKMAPK8MAPK9MAPK10 | |
| SCHEMBL1962067 | 0.82 | GCK (0.59) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513103-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. Hoffmann-La Roche AG (CH) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011073117-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-23 | — | — | WO | disclosed |