Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.61 |
| ▸ | WNT1 | P04628 | 7/20 | 0.61 |
| ▸ | CLK2 | P49760 | 1/20 | 0.54 |
| ▸ | CLK3 | P49761 | 1/20 | 0.54 |
| ▸ | CCNK | O75909 | 2/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CDK7 | P50613 | 2/20 | 0.47 |
| ▸ | CCNH | P51946 | 2/20 | 0.47 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.47 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | BACE1 | P56817 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22596801 | 0.84 | DYRK1A (0.60) | GSK3BDYRK1AWNT1ABL1 | |
| SCHEMBL20414850 | 0.83 | GSK3B (0.61) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL20414809 | 0.83 | GSK3B (0.58) | GSK3BDYRK1AWNT1ABL1 | |
| SCHEMBL20414820 | 0.80 | GSK3B (0.63) | GSK3BDYRK1AWNT1 | |
| SCHEMBL22596795 | 0.79 | GSK3B (0.62) | GSK3BDYRK1AWNT1ABL1 | |
| SCHEMBL23741168 | 0.78 | GSK3B (0.61) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL22596852 | 0.77 | GSK3B (0.54) | GSK3BDYRK1AWNT1 | |
| SCHEMBL24219769 | 0.77 | GSK3B (0.57) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL19516303 | 0.76 | GSK3B (1.00) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL30004736 | 0.76 | GSK3B (1.00) | GSK3BDYRK1AWNT1CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10287267-B2 | Isoquinolin-3-yl carboxamides and preparation and use thereof | SAMUMED, LLC (US) | 2019-05-14 | — | — | US | disclosed |
| US-20180208580-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | VICKERS VENTURE FUND VI PTE. LTD. (SG) | 2018-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10287267-B2 | Isoquinolin-3-yl carboxamides and preparation and use thereof | DYRK1A, DYRK3, DYRK1B | GSK3B 10/4885DYRK1A 1/4885WNT1 7/4885 |
| US-20180208580-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | DYRK1A, DYRK3, DYRK1B | GSK3B 10/4885DYRK1A 1/4885WNT1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.