Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20436665 | 1.00 | MAPT (0.35) | MAPTPDE10ACYP19A1CNR1ALDH1A1 | |
| SCHEMBL20436664 | 1.00 | MAPT (0.35) | MAPTPDE10ACYP19A1CNR1ALDH1A1 | |
| SCHEMBL20416733 | 0.91 | CYP19A1 (0.35) | MAPTPDE10ACYP19A1CNR1ALDH1A1 | |
| SCHEMBL20436706 | 0.91 | CYP19A1 (0.35) | MAPTPDE10ACYP19A1CNR1ALDH1A1 | |
| SCHEMBL20436729 | 0.91 | CYP19A1 (0.35) | MAPTPDE10ACYP19A1CNR1ALDH1A1 | |
| SCHEMBL20400935 | 0.88 | NOTUM (0.37) | LRRK2ADORA2AADORA2BCDC7DAPK3 | |
| SCHEMBL20400933 | 0.88 | NOTUM (0.37) | LRRK2ADORA2AADORA2BCDC7DAPK3 | |
| SCHEMBL20421973 | 0.88 | NOTUM (0.37) | LRRK2ADORA2AADORA2BCDC7DAPK3 | |
| SCHEMBL30400769 | 0.88 | NOTUM (0.37) | LRRK2ADORA2AADORA2BCDC7DAPK3 | |
| SCHEMBL20416678 | 0.88 | NOTUM (0.37) | LRRK2ADORA2AADORA2BCDC7DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018136700-A1 | AZOLOPYRIMIDINE FOR THE TREATMENT OF CANCER-RELATED DISORDERS | ARCUS BIOSCIENCES, INC. (US) | 2018-07-26 | — | — | WO | disclosed |