Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 8/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.35 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16050424 | 0.86 | KDM5A (0.39) | KDM5ACRHBPCRHR2KDM4DTNF | |
| SCHEMBL17085743 | 0.82 | PTGS1 (0.40) | KDM5AKDM6BKDM5CKDM5DKDM4C | |
| SCHEMBL16092249 | 0.76 | KDM5A (0.47) | KDM5AKDM6BKDM5CKDM5DKDM4C | |
| SCHEMBL16092280 | 0.75 | TTK (0.41) | KDM5AKDM6BKDM5CKDM5DKDM4C | |
| SCHEMBL16092513 | 0.74 | KDM5A (0.46) | KDM5AKDM6BKDM5CKDM5DKDM4C | |
| SCHEMBL16050668 | 0.73 | KDM5A (0.52) | KDM5AKDM6BKDM5CKDM5DKDM4C | |
| SCHEMBL16050428 | 0.73 | KDM5A (0.50) | KDM5AKDM6BKDM5CKDM5DKDM4C | |
| SCHEMBL17549523 | 0.72 | TLR8 (0.39) | KDM5AKDM6BKDM5CKDM5DKDM4C | |
| SCHEMBL17549513 | 0.72 | KDM5A (0.47) | KDM5AKDM6BKDM5CKDM5DKDM4C | |
| SCHEMBL16092243 | 0.71 | KDM5A (0.43) | KDM5AKDM6BKDM5CKDM5DKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10035801-B2 | Pyrazolo compounds and uses thereof | GENENTECH, INC. (US) | 2018-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10035801-B2 | Pyrazolo compounds and uses thereof | KDM5A, KDM5C, KDM5B | KDM5A 1/4885CRHBP 4304/4885CRHR2 4250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.