Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | HPGD | P15428 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | KDM5A | P29375 | 5/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | FPR1 | P21462 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16046401 | 0.88 | KDM4D (0.40) | KDM4DALDH1A1HPGDKDM4EKDM5A | |
| SCHEMBL16077838 | 0.80 | KDM4D (0.39) | KDM4DALDH1A1HPGDKDM4EKDM5A | |
| SCHEMBL16046459 | 0.76 | KDM5A (0.48) | KDM4DALDH1A1HPGDKDM4EKDM5A | |
| SCHEMBL16046971 | 0.72 | KDM4D (0.41) | KDM4DALDH1A1HPGDKDM4EKDM5A | |
| SCHEMBL16046982 | 0.69 | KDM5A (0.48) | KDM4DALDH1A1HPGDKDM4EKDM5A | |
| SCHEMBL16077819 | 0.69 | HPGD (0.47) | KDM4DALDH1A1HPGDKDM4EKDM5A | |
| SCHEMBL16046985 | 0.68 | KDM5A (0.47) | KDM4DALDH1A1HPGDKDM4EKDM5A | |
| SCHEMBL16077820 | 0.67 | KDM5A (0.43) | KDM4DALDH1A1HPGDKDM4EKDM5A | |
| SCHEMBL16047079 | 0.67 | KDM5A (0.41) | KDM4DALDH1A1HPGDKDM4EKDM5A | |
| SCHEMBL16046146 | 0.63 | KDM5A (0.45) | KDM4DALDH1A1HPGDKDM4EKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10035801-B2 | Pyrazolo compounds and uses thereof | GENENTECH, INC. (US) | 2018-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10035801-B2 | Pyrazolo compounds and uses thereof | KDM5A, KDM5C, KDM5B | KDM4D 18/4885ALDH1A1 1424/4885HPGD 1427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.