Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.64 |
| ▸ | FLT1 | P17948 | 14/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 12/20 | 0.57 |
| ▸ | KIT | P10721 | 11/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | CSF1R | P07333 | 2/20 | 0.50 |
| ▸ | FLT4 | P35916 | 2/20 | 0.50 |
| ▸ | CIT | O14578 | 1/20 | 0.50 |
| ▸ | HLA-A | P04439 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.50 |
| ▸ | FRK | P42685 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.50 |
| ▸ | STK3 | Q13188 | 1/20 | 0.50 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.50 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.50 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20431372 | 0.85 | KDR (0.73) | KDRFLT1PDGFRBKITEGFR | |
| SCHEMBL906268 | 0.79 | KDR (0.80) | KDRFLT1PDGFRBKITEGFR | |
| SCHEMBL4818044 | 0.77 | KDR (0.79) | KDRFLT1PDGFRBKITEGFR | |
| SCHEMBL20431365 | 0.76 | FLT1 (0.56) | KDRFLT1PDGFRBKITSMN1; SMN2 | |
| SCHEMBL20431246 | 0.75 | FLT1 (0.57) | KDRFLT1PDGFRBKITEGFR | |
| SCHEMBL24996489 | 0.73 | FLT1 (0.66) | KDRFLT1PDGFRBKITEGFR | |
| SCHEMBL905634 | 0.73 | KDR (1.00) | KDRFLT1PDGFRBKITEGFR | |
| Trifluoromethylbenzene SCHEMBL27625245 | 0.73 | KDR (0.54) | KDRFLT1PDGFRBKITSMN1; SMN2 | |
| SCHEMBL905657 | 0.72 | FLT1 (0.68) | KDRFLT1PDGFRBKITEGFR | |
| Hydrochloric Acid SCHEMBL6610350 | 0.72 | KDR (0.97) | KDRFLT1PDGFRBKITEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137162-B1 | ORGANIC COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2018-08-01 | — | — | EP | disclosed |