Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17079011 | 1.00 | HDAC1 (0.53) | HDAC1HDAC6SMN1; SMN2LMNAHTT | |
| SCHEMBL20420900 | 0.89 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNAHTTL3MBTL1ALDH1A1 | |
| SCHEMBL17078581 | 0.87 | MAPT (0.51) | SMN1; SMN2LMNAHTTL3MBTL1ALDH1A1 | |
| SCHEMBL17078504 | 0.87 | HDAC1 (0.57) | HDAC1HDAC6SMN1; SMN2HDAC4KCNH2 | |
| SCHEMBL17086798 | 0.87 | SMN1; SMN2 (0.54) | HDAC1HDAC6SMN1; SMN2LMNAHTT | |
| SCHEMBL17078569 | 0.83 | HDAC1 (0.53) | HDAC1HDAC6SMN1; SMN2LMNAHTT | |
| SCHEMBL17078771 | 0.81 | HDAC1 (0.58) | HDAC1HDAC6HDAC4KCNH2HDAC8 | |
| SCHEMBL20432798 | 0.80 | HDAC1 (0.60) | HDAC1HDAC6HDAC4KCNH2HDAC8 | |
| SCHEMBL17078910 | 0.80 | HDAC1 (0.60) | HDAC1HDAC6HDAC4KCNH2HDAC8 | |
| SCHEMBL17078795 | 0.79 | HDAC1 (0.68) | HDAC1HDAC6SMN1; SMN2LMNAHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116859-B1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP (KR) | 2018-08-01 | — | — | EP | disclosed |