Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.73 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | CHKA | P35790 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17078574 | 1.00 | HDAC6 (0.73) | HDAC6HDAC1HDAC4KCNH2HDAC8 | |
| SCHEMBL17078890 | 0.91 | HDAC6 (0.63) | HDAC6HDAC1HDAC4KCNH2HDAC8 | |
| SCHEMBL17078986 | 0.91 | HDAC1 (0.69) | HDAC6HDAC1HDAC4KCNH2HDAC8 | |
| SCHEMBL17079009 | 0.90 | HDAC1 (0.67) | HDAC6HDAC1HDAC4KCNH2HDAC8 | |
| SCHEMBL17079020 | 0.88 | HDAC6 (0.76) | HDAC6HDAC1HDAC4KCNH2HDAC8 | |
| SCHEMBL17078846 | 0.88 | NPC1 (0.56) | HDAC6HDAC1HDAC4KCNH2HDAC8 | |
| SCHEMBL20432675 | 0.88 | NPC1 (0.56) | HDAC6HDAC1HDAC4KCNH2HDAC8 | |
| SCHEMBL20432863 | 0.87 | HDAC6 (0.56) | HDAC6HDAC1HDAC4KCNH2HDAC8 | |
| SCHEMBL20432690 | 0.87 | HDAC1 (0.62) | HDAC6HDAC1HDAC4KCNH2HDAC8 | |
| SCHEMBL17078879 | 0.87 | HDAC1 (0.62) | HDAC6HDAC1HDAC4KCNH2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116859-B1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP (KR) | 2018-08-01 | — | — | EP | disclosed |