Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 20/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19672651 | 0.96 | ATR (0.47) | ATRATM | |
| SCHEMBL20433529 | 0.91 | ATR (0.53) | ATRATM | |
| SCHEMBL19672616 | 0.88 | ATR (0.46) | ATRATM | |
| SCHEMBL19672655 | 0.88 | ATR (0.47) | ATR | |
| SCHEMBL20433577 | 0.87 | ATR (0.52) | ATR | |
| SCHEMBL19672692 | 0.86 | ATR (0.51) | ATRATM | |
| SCHEMBL20433548 | 0.86 | ATR (0.58) | ATR | |
| SCHEMBL29458652 | 0.86 | ATR (0.47) | ATRATM | |
| SCHEMBL3052935 | 0.86 | ATR (0.47) | ATRATM | |
| SCHEMBL19672752 | 0.85 | ATR (0.47) | ATRATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3354650-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | Vertex Pharmaceuticals Incorporated (US) | 2018-08-01 | — | — | EP | disclosed |