Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 20/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20433401 | 0.93 | ATR (0.54) | ATRATMGSK3BPRKDC | |
| SCHEMBL20433569 | 0.92 | ATR (0.56) | ATRATMGSK3BPRKDC | |
| SCHEMBL20433572 | 0.91 | ATR (0.45) | ATRATM | |
| SCHEMBL20433282 | 0.88 | ATR (0.52) | ATRATMGSK3BPRKDC | |
| SCHEMBL20433489 | 0.86 | ATR (0.63) | ATRATMGSK3BPRKDC | |
| SCHEMBL19672784 | 0.86 | ATR (0.50) | ATRATMGSK3BPRKDC | |
| SCHEMBL3048169 | 0.85 | ATR (0.56) | ATRATMGSK3BPRKDC | |
| SCHEMBL3052509 | 0.85 | ATR (0.56) | ATRATMGSK3BPRKDC | |
| SCHEMBL3048165 | 0.85 | ATR (0.56) | ATRATMGSK3BPRKDC | |
| SCHEMBL20433601 | 0.85 | ATR (0.53) | ATRATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3354650-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | Vertex Pharmaceuticals Incorporated (US) | 2018-08-01 | — | — | EP | disclosed |