Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17489316 | 0.90 | POLB (0.36) | KDM4EKMT2AMAPTMEN1HTR2A | |
| SCHEMBL19035897 | 0.89 | KDM4E (0.31) | KDM4E | |
| SCHEMBL18973168 | 0.89 | KDM4E (0.31) | KDM4E | |
| SCHEMBL14090164 | 0.87 | HTR2A (0.33) | KDM4EALDH1A1HTR2AHTR2CHTR2B | |
| SCHEMBL19657863 | 0.86 | AURKA (0.34) | CHEK1 | |
| SCHEMBL17476448 | 0.86 | AURKA (0.34) | CHEK1 | |
| SCHEMBL12347417 | 0.86 | — | — | |
| SCHEMBL22166375 | 0.85 | POLB (0.33) | KDM4E | |
| SCHEMBL19639232 | 0.84 | PDE4B (0.31) | — | |
| SCHEMBL20169652 | 0.82 | PDE4B (0.39) | KMT2AMEN1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3470086-B1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MEDIMMUNE LTD (GB) | 2020-11-25 | — | — | EP | disclosed |
| EP-2906253-B1 | PYRROLOBENZODIAZEPINE - ANTI-PSMA ANTIBODY CONJUGATES | ADC THERAPEUTICS SA (CH) | 2018-08-01 | — | — | EP | disclosed |