Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | GPR3 | P46089 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 11/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20438144 | 0.95 | AHR (0.44) | AHRPGRALDH1A1HSD17B10GPR3 | |
| SCHEMBL20437689 | 0.90 | AHR (0.41) | AHRPGRALDH1A1HSD17B10GPR3 | |
| SCHEMBL802247 | 0.89 | AHR (0.55) | AHRPGRALDH1A1HSD17B10GPR3 | |
| SCHEMBL802805 | 0.89 | AHR (0.55) | AHRPGRALDH1A1HSD17B10GPR3 | |
| SCHEMBL30487042 | 0.89 | AHR (0.55) | AHRPGRALDH1A1HSD17B10GPR3 | |
| SCHEMBL21217586 | 0.88 | AHR (0.47) | AHRPGRALDH1A1HSD17B10GPR3 | |
| SCHEMBL20199486 | 0.87 | AHR (0.53) | AHRPGRALDH1A1HSD17B10GPR3 | |
| SCHEMBL20437694 | 0.84 | AHR (0.44) | AHRPGRALDH1A1HSD17B10GPR3 | |
| SCHEMBL23231541 | 0.83 | AHR (0.42) | AHRPGRALDH1A1HSD17B10GPR3 | |
| SCHEMBL2603647 | 0.83 | AHR (0.55) | AHRPGRALDH1A1HSD17B10GPR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10964894-B2 | Carbazole derivatives | MERCK PATENT GMBH (DE) | 2021-03-30 | — | — | US | disclosed |
| US-20190348616-A1 | CARBAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-11-14 | — | — | US | disclosed |
| WO-2018138039-A1 | CARBAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190348616-A1 | CARBAZOLE DERIVATIVES | CYP2E1, CYP3A4, CYP2C19 | AHR 140/4885PGR 3036/4885ALDH1A1 425/4885 |
| US-10964894-B2 | Carbazole derivatives | CYP2E1, CYP3A4, CYP2C19 | AHR 140/4885PGR 3036/4885ALDH1A1 425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.