Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 20/20 | 0.55 |
| ▸ | PRKCB | P05771 | 6/20 | 0.55 |
| ▸ | CDK4 | P11802 | 6/20 | 0.55 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.55 |
| ▸ | GSK3A | P49840 | 16/20 | 0.53 |
| ▸ | CDK2 | P24941 | 5/20 | 0.53 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.53 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.53 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.53 |
| ▸ | PRKCG | P05129 | 2/20 | 0.53 |
| ▸ | LCK | P06239 | 2/20 | 0.53 |
| ▸ | CDK1 | P06493 | 2/20 | 0.53 |
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | CLK2 | P49760 | 2/20 | 0.53 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.53 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.53 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.53 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20439107 | 0.96 | GSK3B (0.56) | GSK3BPRKCBCDK4TGFBR2GSK3A | |
| SCHEMBL21577692 | 0.91 | GSK3B (0.66) | GSK3BPRKCBCDK4TGFBR2GSK3A | |
| SCHEMBL29534131 | 0.91 | GSK3B (0.66) | GSK3BPRKCBCDK4TGFBR2GSK3A | |
| SCHEMBL20439085 | 0.91 | GSK3B (0.58) | GSK3BPRKCBCDK4TGFBR2GSK3A | |
| SCHEMBL20439153 | 0.91 | GSK3B (0.66) | GSK3BPRKCBCDK4TGFBR2GSK3A | |
| SCHEMBL20439082 | 0.89 | GSK3B (0.57) | GSK3BPRKCBCDK4TGFBR2GSK3A | |
| SCHEMBL20439227 | 0.89 | GSK3B (0.65) | GSK3BPRKCBCDK4TGFBR2GSK3A | |
| SCHEMBL20439152 | 0.87 | GSK3B (0.67) | GSK3BPRKCBCDK4TGFBR2GSK3A | |
| SCHEMBL20439084 | 0.87 | GSK3B (0.56) | GSK3BPRKCBCDK4TGFBR2GSK3A | |
| SCHEMBL22510842 | 0.86 | GSK3B (0.52) | GSK3BPRKCBCDK4TGFBR2GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10383881-B2 | 1,5-dihydro-2H-pyrrol-2-one compounds and methods of using same | Frequency Therapeutics, Inc. (US) | 2019-08-20 | — | — | US | disclosed |
| US-20180214458-A1 | 1,5-DIHYDRO-2H-PYRROL-2-ONE COMPOUNDS AND METHODS OF USING SAME | Frequency Therapeutics, Inc. | 2018-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180214458-A1 | 1,5-DIHYDRO-2H-PYRROL-2-ONE COMPOUNDS AND METHODS OF USING SAME | DCX, MKI67, MCL1 | GSK3B 3480/4885PRKCB 2056/4885CDK4 79/4885 |
| US-10383881-B2 | 1,5-dihydro-2H-pyrrol-2-one compounds and methods of using same | DCX, MKI67, MCL1 | GSK3B 3480/4885PRKCB 2056/4885CDK4 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.