Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 6/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.37 |
| ▸ | KLK7 | P49862 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | YAP1 | P46937 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20437214 | 1.00 | MEN1 (0.43) | MEN1POLBKMT2ABCL2P2RX7 | |
| SCHEMBL20422541 | 0.94 | MEN1 (0.48) | MEN1POLBKMT2ABCL2P2RX7 | |
| SCHEMBL20422540 | 0.94 | MEN1 (0.48) | MEN1POLBKMT2ABCL2P2RX7 | |
| SCHEMBL20437154 | 0.89 | MEN1 (0.44) | MEN1POLBKMT2ABCL2P2RX7 | |
| SCHEMBL20422562 | 0.89 | MEN1 (0.44) | MEN1POLBKMT2ABCL2P2RX7 | |
| SCHEMBL20437157 | 0.81 | MEN1 (0.49) | MEN1POLBKMT2ABCL2P2RX7 | |
| SCHEMBL21626648 | 0.80 | MEN1 (0.43) | MEN1POLBKMT2ABCL2KLK5 | |
| SCHEMBL20437152 | 0.79 | BCL2 (0.40) | MEN1POLBKMT2ABCL2P2RX7 | |
| SCHEMBL20437150 | 0.79 | BCL2 (0.40) | MEN1POLBKMT2ABCL2P2RX7 | |
| SCHEMBL20806019 | 0.77 | MEN1 (0.37) | MEN1POLBKMT2ABCL2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3573987-B1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARM SPA (IT) | 2021-03-10 | — | — | EP | disclosed |
| WO-2018138293-A1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-08-02 | — | — | WO | disclosed |