Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 4/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.57 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9216879 | 0.82 | PIK3CA (0.75) | JAK3HRH4PIK3R1PIK3CAHSD17B10 | |
| SCHEMBL1017284 | 0.81 | JAK3 (0.58) | JAK3HRH4PIK3R1PIK3CAHTR2C | |
| SCHEMBL14320465 | 0.81 | HRH4 (0.78) | JAK3HRH4PIK3R1PIK3CAMAP2K7 | |
| SCHEMBL1444374 | 0.81 | JAK3 (0.58) | JAK3HRH4PIK3R1PIK3CAHTR2C | |
| SCHEMBL18900790 | 0.80 | JAK3 (0.54) | JAK3HRH4PIK3R1PIK3CAHTR2C | |
| SCHEMBL1018704 | 0.79 | JAK3 (0.59) | JAK3HRH4PIK3R1PIK3CAMEN1 | |
| SCHEMBL14320582 | 0.79 | HRH4 (0.76) | JAK3HRH4PIK3R1PIK3CAMAP2K7 | |
| SCHEMBL2044205 | 0.74 | PIK3R1 (0.52) | JAK3HRH4PIK3R1PIK3CAMEN1 | |
| SCHEMBL1818852 | 0.73 | JAK3 (1.00) | JAK3HTR2CLCKKITAKT2 | |
| SCHEMBL31143483 | 0.72 | HRH4 (0.44) | JAK3HRH4PIK3R1PIK3CAHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110160185-A9 | PYRROLOPYRIMIDINE DERIVATIVES AS JAK3 INHIBITORS | PALAU PHARMA, S.A. (ES) | 2011-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160185-A9 | PYRROLOPYRIMIDINE DERIVATIVES AS JAK3 INHIBITORS | JAK3, JAK2, JAK1 | JAK3 1/4885HRH4 1763/4885PIK3R1 495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.