Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 19/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29447689 | 1.00 | KRAS (0.50) | KRASFGFR4 | |
| SCHEMBL29447768 | 0.95 | KRAS (0.47) | KRAS | |
| SCHEMBL20443594 | 0.95 | KRAS (0.47) | KRAS | |
| SCHEMBL29447728 | 0.93 | KRAS (0.52) | KRAS | |
| SCHEMBL20443691 | 0.93 | KRAS (0.52) | KRAS | |
| SCHEMBL29447729 | 0.87 | KRAS (0.49) | KRAS | |
| SCHEMBL20443494 | 0.87 | KRAS (0.49) | KRAS | |
| SCHEMBL29447726 | 0.83 | KRAS (0.46) | KRAS | |
| SCHEMBL20443493 | 0.83 | KRAS (0.46) | KRAS | |
| SCHEMBL20443642 | 0.81 | KRAS (0.52) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11274093-B2 | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof | ARAXES PHARMA LLC (US) | 2022-03-15 | — | — | US | disclosed |
| WO-2018140512-A1 | FUSED BICYCLIC BENZOHETEROAROMATIC COMPOUNDS AND METHODS OF USE THEREOF | ARAXES PHARMA LLC (US) | 2018-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11274093-B2 | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof | KRAS, NRAS, HRAS | KRAS 1/4885FGFR4 1171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.