Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 9/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20446506 | 1.00 | CYP1A2 (0.42) | CYP1A2POLBCYP3A4CYP2C19KLKB1 | |
| SCHEMBL20446602 | 0.91 | CYP1A2 (0.43) | CYP1A2POLBCYP3A4CYP2C19KLKB1 | |
| SCHEMBL20446617 | 0.91 | CYP1A2 (0.43) | CYP1A2POLBCYP3A4CYP2C19KLKB1 | |
| SCHEMBL20446536 | 0.84 | KLKB1 (0.38) | CYP1A2POLBCYP3A4CYP2C19KLKB1 | |
| SCHEMBL20584575 | 0.81 | KLKB1 (0.51) | CYP1A2POLBCYP3A4CYP2C19KLKB1 | |
| SCHEMBL20584573 | 0.81 | KLKB1 (0.51) | CYP1A2POLBCYP3A4CYP2C19KLKB1 | |
| SCHEMBL20446447 | 0.81 | KLKB1 (0.51) | CYP1A2POLBCYP3A4CYP2C19KLKB1 | |
| SCHEMBL24012307 | 0.80 | CYP1A2 (0.49) | CYP1A2POLBCYP3A4CYP2C19KLKB1 | |
| SCHEMBL31456830 | 0.79 | CYP1A2 (0.46) | CYP1A2POLBCYP3A4CYP2C19KLKB1 | |
| SCHEMBL29581125 | 0.79 | CYP1A2 (0.46) | CYP1A2POLBCYP3A4CYP2C19KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3355890-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2018-08-08 | — | — | EP | disclosed |