Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 18/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31456805 | 1.00 | KLKB1 (0.45) | KLKB1CYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL20584684 | 1.00 | KLKB1 (0.45) | KLKB1CYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL22685920 | 0.92 | KLKB1 (0.45) | KLKB1CYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL29489465 | 0.92 | KLKB1 (0.45) | KLKB1CYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL21726714 | 0.92 | KLKB1 (0.45) | KLKB1CYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL20446649 | 0.92 | KLKB1 (0.45) | KLKB1CYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL20584253 | 0.90 | KLKB1 (0.47) | KLKB1CYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL31456804 | 0.90 | KLKB1 (0.47) | KLKB1CYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL29692967 | 0.88 | KLKB1 (0.60) | KLKB1POLB | |
| SCHEMBL20584468 | 0.88 | KLKB1 (0.60) | KLKB1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3355890-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2018-08-08 | — | — | EP | disclosed |