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SCHEMBL20450378

SCHEMBL20450378

CCCCCC1(c2ccc(F)cc2)CN(C(=O)C(Cc2ccc(OC)cc2)NC(=O)CCc2c[nH]cn2)C1

nearest known ligand 0.49

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ MC1R Q01726 9/20 0.49
▸ MC4R P32245 9/20 0.49
▸ KMT2A Q03164 1/20 0.41
▸ MC5R P33032 1/20 0.38
▸ MC3R P41968 1/20 0.38
▸ ITGB3 P05106 2/20 0.34
▸ ITGA2B P08514 2/20 0.34
▸ HRH2 P25021 2/20 0.34
▸ HRH1 P35367 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1309688 1.00 MC1R (0.49) MC1RMC4RKMT2AMC5RMC3R
SCHEMBL2154100 0.94 MC4R (0.56) MC1RMC4RKMT2AMC5RMC3R
SCHEMBL20450420 0.94 MC4R (0.49) MC1RMC4RMC5RMC3RITGB3
SCHEMBL1311002 0.94 MC4R (0.49) MC1RMC4RMC5RMC3RITGB3
SCHEMBL1310742 0.93 MC4R (0.53) MC1RMC4RMC5RMC3RITGB3
SCHEMBL20450393 0.93 MC4R (0.53) MC1RMC4RMC5RMC3RITGB3
SCHEMBL1310703 0.92 MC4R (0.49) MC1RMC4RKMT2AMC5RMC3R
SCHEMBL20450402 0.92 MC4R (0.49) MC1RMC4RKMT2AMC5RMC3R
SCHEMBL2154280 0.92 MC4R (0.53) MC1RMC4RMC5RMC3RITGB3
SCHEMBL20450434 0.91 MC4R (0.51) MC1RMC4RMC5RMC3RITGB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2342194-B1 OXOAZETIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS GALDERMA RES & DEV (FR) 2018-08-08 — — EP claimed