Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 16/20 | 0.71 |
| ▸ | BRDT | Q58F21 | 6/20 | 0.59 |
| ▸ | BRD2 | P25440 | 4/20 | 0.59 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.59 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | BRD1 | O95696 | 1/20 | 0.59 |
| ▸ | CCL2 | P13500 | 1/20 | 0.59 |
| ▸ | EP300 | Q09472 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20285975 | 0.93 | BRD4 (0.62) | BRD4BRDTBRD2BRD3HDAC3 | |
| SCHEMBL21516324 | 0.91 | BRD4 (0.60) | BRD4BRDTBRD2BRD3HDAC3 | |
| SCHEMBL881210 | 0.91 | BRD4 (0.72) | BRD4BRDTBRD2BRD3HDAC3 | |
| SCHEMBL17059522 | 0.91 | BRD4 (0.72) | BRD4BRDTBRD2BRD3HDAC3 | |
| SCHEMBL12152376 | 0.85 | BRD4 (0.67) | BRD4BRDTBRD2BRD3HDAC3 | |
| SCHEMBL881280 | 0.85 | BRD4 (0.67) | BRD4BRDTBRD2BRD3HDAC3 | |
| SCHEMBL17854798 | 0.85 | BRD4 (0.52) | BRD4BRDTBRD2BRD3HDAC3 | |
| SCHEMBL18551346 | 0.83 | BRD4 (1.00) | BRD4BRDTBRD2BRD3HDAC3 | |
| SCHEMBL18551348 | 0.83 | BRD4 (1.00) | BRD4BRDTBRD2BRD3HDAC3 | |
| SCHEMBL12152639 | 0.83 | BRD4 (1.00) | BRD4BRDTBRD2BRD3HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10336771-B2 | Compounds targeting proteins, compositions, methods, and uses thereof | BIOTHERYX, INC. (US) | 2019-07-02 | — | — | US | disclosed |
| US-10040804-B2 | Compounds targeting proteins, compositions, methods, and uses thereof | BIOTHERYX, INC. (US) | 2018-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10336771-B2 | Compounds targeting proteins, compositions, methods, and uses thereof | CKS1B, IKZF3, EPAS1 | BRD4 1090/4885BRDT 2418/4885BRD2 3439/4885 |
| US-10040804-B2 | Compounds targeting proteins, compositions, methods, and uses thereof | CKS1B, IKZF3, EPAS1 | BRD4 1090/4885BRDT 2418/4885BRD2 3439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.