Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 17/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15901365 | 0.93 | IDH1 (0.44) | IDH1PIK3CDPIK3R1GRM1 | |
| SCHEMBL14249966 | 0.93 | IDH1 (0.44) | IDH1PIK3CDPIK3R1GRM1 | |
| SCHEMBL14250795 | 0.91 | IDH1 (0.52) | IDH1 | |
| SCHEMBL15900889 | 0.91 | IDH1 (0.52) | IDH1 | |
| SCHEMBL17996938 | 0.85 | MAP4K4 (0.39) | IDH1GRM1 | |
| SCHEMBL14250205 | 0.84 | IDH1 (0.49) | IDH1 | |
| SCHEMBL14315319 | 0.84 | IDH1 (0.49) | IDH1 | |
| SCHEMBL14250336 | 0.83 | IDH1 (0.52) | IDH1 | |
| SCHEMBL14250335 | 0.83 | IDH1 (0.52) | IDH1 | |
| SCHEMBL14315350 | 0.82 | IDH1 (0.35) | IDH1PIK3CDPIK3R1GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2721019-B1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE | AGIOS PHARMACEUTICALS INC (US) | 2018-08-08 | — | — | EP | disclosed |