Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17838289 | 0.79 | POLB (0.36) | POLBAPEX1NPC1HTTRAB9A | |
| SCHEMBL19881944 | 0.75 | BRD4 (0.39) | ALDH1A1 | |
| SCHEMBL28854915 | 0.71 | POLB (0.34) | POLBAPEX1NPC1HTTRAB9A | |
| SCHEMBL28854899 | 0.69 | POLB (0.36) | POLBAPEX1NPC1HTTRAB9A | |
| SCHEMBL20458728 | 0.68 | ATM (0.48) | SMN1; SMN2 | |
| SCHEMBL16416854 | 0.68 | SMN1; SMN2 (0.33) | NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL28194798 | 0.67 | HTT (0.38) | POLBAPEX1NPC1HTTRAB9A | |
| SCHEMBL28194841 | 0.66 | POLB (0.40) | POLBAPEX1NPC1HTTRAB9A | |
| SCHEMBL16417232 | 0.65 | NR4A2 (0.35) | POLBAPEX1 | |
| SCHEMBL21408397 | 0.65 | KDM4E (0.35) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3357906-A1 | GLYOXAMIDE SUBSTITUTED PYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | Janssen Sciences Ireland UC (IE) | 2018-08-08 | — | — | EP | disclosed |