Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 20/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20388734 | 0.93 | PTPN11 (0.69) | PTPN11 | |
| SCHEMBL20461028 | 0.89 | PTPN11 (0.70) | PTPN11 | |
| SCHEMBL20461075 | 0.88 | PTPN11 (0.70) | PTPN11 | |
| SCHEMBL20388729 | 0.87 | PTPN11 (0.74) | PTPN11 | |
| SCHEMBL20460881 | 0.86 | PTPN11 (0.70) | PTPN11 | |
| SCHEMBL24878996 | 0.86 | PTPN11 (0.59) | PTPN11 | |
| SCHEMBL20460836 | 0.85 | PTPN11 (0.54) | PTPN11 | |
| SCHEMBL21154439 | 0.85 | PTPN11 (0.59) | PTPN11 | |
| SCHEMBL20460926 | 0.85 | PTPN11 (0.55) | PTPN11 | |
| SCHEMBL27132603 | 0.83 | PTPN11 (0.53) | PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3094628-B1 | N-AZASPIROCYCLOALKANE SUBSTITUTED N-HETEROARYL COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS AG (CH) | 2018-08-08 | — | — | EP | disclosed |