Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 16/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.38 |
| ▸ | MLNR | O43193 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20437007 | 1.00 | ESR1 (0.39) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL20443265 | 1.00 | ESR1 (0.39) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL20443266 | 0.88 | ESR1 (0.41) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL20437004 | 0.88 | ESR1 (0.41) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL20437006 | 0.85 | ESR1 (0.41) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL20443264 | 0.85 | ESR1 (0.41) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL20463086 | 0.85 | ESR1 (0.41) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL20463152 | 0.74 | ESR1 (0.42) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL20436992 | 0.73 | CYP4F2 (0.37) | HRH3CYP4F2CYP4A11 | |
| SCHEMBL30479970 | 0.70 | ESR1 (0.49) | ESR1ESR2MLNRNR1I2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018144649-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | Arvinas, Inc. (US) | 2018-08-09 | — | — | WO | disclosed |