⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL295409 | 0.97 | — | — | |
| SCHEMBL29765319 | 0.97 | — | — | |
| Cyanide SCHEMBL27694642 | 0.91 | TDP1 (0.44) | — | |
| Formaldehyde SCHEMBL27932784 | 0.91 | TDP1 (0.48) | — | |
| Pyridine SCHEMBL28874985 | 0.87 | TDP1 (0.42) | — | |
| Formic Acid SCHEMBL28064452 | 0.85 | TDP1 (0.48) | — | |
| SCHEMBL30309922 | 0.78 | LCK (0.46) | — | |
| SCHEMBL15784053 | 0.78 | LCK (0.46) | — | |
| SCHEMBL30294833 | 0.77 | — | — | |
| SCHEMBL299697 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11364241-B2 | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) | MEDIVATION TECHNOLOGIES LLC (US) | 2022-06-21 | — | — | US | disclosed |
| US-20210069191-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | MEDIVATION TECHNOLOGIES LLC | 2021-03-11 | — | — | US | disclosed |
| US-10780088-B2 | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) | MEDIVATION TECHNOLOGIES LLC (US) | 2020-09-22 | — | — | US | disclosed |
| US-20200261454-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | MEDIVATION TECHNOLOGIES LLC | 2020-08-20 | — | — | US | disclosed |
| US-10543209-B2 | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) | MEDIVATION TECHNOLOGIES LLC (US) | 2020-01-28 | — | — | US | disclosed |
| US-20180117045-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | MEDIVATION TECHNOLOGIES LLC | 2018-05-03 | — | — | US | disclosed |
| US-9820985-B2 | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) | MEDIVATION TECHNOLOGIES LLC (US) | 2017-11-21 | — | — | US | disclosed |
| EP-3241832-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | Medivation Technologies, Inc. (US) | 2017-11-08 | — | — | EP | disclosed |
| EP-2767537-B1 | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) | MEDIVATION TECHNOLOGIES INC (US) | 2017-04-12 | — | — | EP | disclosed |
| US-20150209357-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | MEDIVATION TECHNOLOGIES LLC | 2015-07-30 | — | — | US | disclosed |
| EP-2767537-A1 | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) | BioMarin Pharmaceutical Inc. (US) | 2014-08-20 | — | — | EP | disclosed |
| EP-2326650-B1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | BIOMARIN PHARM INC (US) | 2014-02-26 | — | — | EP | disclosed |
| US-20130190306-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | BIOMARIN PHARMACEUTICAL INC. (US) | 2013-07-25 | — | — | US | disclosed |
| US-8420650-B2 | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) | BIOMARIN PHARMACEUTICAL INC. (US) | 2013-04-16 | — | — | US | disclosed |
| WO-2011130661-A1 | METHODS OF USING DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY (ADP-RIBOSE)POLYMERASE (PARP) | BIOMARIN PHARMACEUTICAL INC. (US) | 2011-10-20 | — | — | WO | disclosed |
| US-20110237581-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | MEDIVATION TECHNOLOGIES LLC | 2011-09-29 | — | — | US | disclosed |
| US-8012976-B2 | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) | BIOMARIN PHARMACEUTICAL INC. (US) | 2011-09-06 | — | — | US | disclosed |
| EP-2326650-A2 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | BioMarin Pharmaceutical Inc. (US) | 2011-06-01 | — | — | EP | disclosed |
| WO-2010017055-A2 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | LEAD THERAPEUTICS, INC. (US) | 2010-02-11 | — | — | WO | disclosed |
| US-20100035883-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | LEAD THERAPEUTICS, INC. (US) | 2010-02-11 | — | — | US | disclosed |