Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 20/20 | 1.00 |
| ▸ | F10 | P00742 | 12/20 | 1.00 |
| ▸ | PRSS1 | P07477 | 12/20 | 1.00 |
| ▸ | PRSS2 | P07478 | 12/20 | 1.00 |
| ▸ | PRSS3 | P35030 | 12/20 | 1.00 |
| ▸ | F12 | P00748 | 10/20 | 0.94 |
| ▸ | F7 | P08709 | 10/20 | 0.94 |
| ▸ | F9 | P00740 | 3/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6921523 | 1.00 | F2 (1.00) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL20567697 | 1.00 | F2 (1.00) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL15298962 | 0.97 | F2 (1.00) | F2F10PRSS1PRSS2PRSS3 | |
| Trifluoroacetic Acid SCHEMBL16426767 | 0.92 | F2 (1.00) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL17221962 | 0.91 | F2 (1.00) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL17221964 | 0.91 | F2 (1.00) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL6923243 | 0.90 | F2 (1.00) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL17221954 | 0.89 | F2 (0.88) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL17221956 | 0.89 | F2 (0.88) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL17222132 | 0.88 | F2 (1.00) | F2F10PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180340163-A1 | RECOMBINANT SERINE PROTEASES | ACADEMISCH ZIEKENHUIS LEIDEN (NL) | 2018-11-29 | — | — | US | disclosed |
| EP-2830624-B1 | THROMBIN INHIBITORS | MERCK SHARP & DOHME (US) | 2018-09-05 | — | — | EP | disclosed |