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Sugi Predict / Compounds / SCHEMBL20487555

SCHEMBL20487555

SCHEMBL20487555

CNc1ncc2c(n1)N(C1CCN(C(=O)C=CCN(C)C)C1)C(=O)N(c1c(Cl)c(OC)cc(OC)c1Cl)C2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 20/20 1.00
▸ FGFR2 P21802 13/20 0.92
▸ FGFR4 P22455 12/20 0.92
▸ FGFR3 P22607 12/20 0.92

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20487300 1.00 FGFR1 (1.00) FGFR1FGFR2FGFR4FGFR3
SCHEMBL20487413 1.00 FGFR1 (1.00) FGFR1FGFR2FGFR4FGFR3
SCHEMBL20487553 1.00 FGFR1 (1.00) FGFR1FGFR2FGFR4FGFR3
SCHEMBL24080586 0.97 FGFR1 (1.00) FGFR1FGFR2FGFR4FGFR3
SCHEMBL20486833 0.97 FGFR1 (1.00) FGFR1FGFR2FGFR4FGFR3
SCHEMBL20486835 0.97 FGFR1 (1.00) FGFR1FGFR2FGFR4FGFR3
SCHEMBL20487338 0.96 FGFR1 (1.00) FGFR1FGFR2FGFR4FGFR3
SCHEMBL20487686 0.96 FGFR1 (1.00) FGFR1FGFR2FGFR4FGFR3
SCHEMBL24080358 0.93 FGFR1 (0.92) FGFR1FGFR2FGFR4FGFR3
SCHEMBL20486748 0.93 FGFR1 (0.92) FGFR1FGFR2FGFR4FGFR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110809576-B FGFR kinase inhibitor and pharmaceutical use 奥克兰联合服务有限公司 2022-08-30 — — CN claimed
CN-110809576-B FGFR kinase inhibitor and pharmaceutical use 奥克兰联合服务有限公司 2022-08-30 — — CN disclosed
WO-2018160076-A1 FGFR KINASE INHIBITORS AND PHARMACEUTICAL USES AUCKLAND UNISERVICES LIMITED (NZ) 2018-09-07 — — WO disclosed