Sugi Predict

Sugi Predict / Compounds / SCHEMBL20488206

SCHEMBL20488206

SCHEMBL20488206

COCCN1C(C(=O)OC)=CC(c2nccs2)=NS1(=O)=O

nearest known ligand 0.43

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 12/20 0.43
▸ KMT2A Q03164 12/20 0.43
▸ MAPT P10636 3/20 0.38
▸ POLB P06746 1/20 0.38
▸ ALDH1A1 P00352 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ KLK7 P49862 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20487250 0.94 MEN1 (0.39) MEN1KMT2AMAPTPOLBALDH1A1
SCHEMBL20486988 0.91 KMT2A (0.37) MEN1KMT2AMAPTPOLBALDH1A1
SCHEMBL20487200 0.90 MEN1 (0.36) MEN1KMT2AMAPTPOLBKLK7
SCHEMBL20486795 0.90 MEN1 (0.36) MEN1KMT2AMAPTPOLB
SCHEMBL20486711 0.89 MEN1 (0.36) MEN1KMT2AMAPTPOLBSMN1; SMN2
SCHEMBL20487713 0.87 MEN1 (0.38) MEN1KMT2AMAPTPOLBKLK7
SCHEMBL20487193 0.86 MEN1 (0.37) MEN1KMT2AMAPTPOLB
SCHEMBL20487909 0.85 MEN1 (0.36) MEN1KMT2AMAPTPOLB
SCHEMBL20487332 0.85 MEN1 (0.41) MEN1KMT2AMAPTPOLB
SCHEMBL20488192 0.84 MEN1 (0.49) MEN1KMT2AMAPTPOLBKLK7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230012463-A1 CYCLIC SULFAMIDE COMPOUNDS AND METHODS OF USING SAME ASSEMBLY BIOSCIENCES INC (US) 2023-01-12 — — US disclosed
US-11078170-B2 Cyclic sulfamide compounds and methods of using same ASSEMBLY BIOSCIENCES, INC. (US) 2021-08-03 — — US disclosed
US-11078170-B2 Cyclic sulfamide compounds and methods of using same ASSEMBLY BIOSCIENCES, INC. (US) 2021-08-03 — — US disclosed
EP-3589630-B1 CYCLIC SULFAMIDE COMPOUNDS AND METHODS OF USING SAME ASSEMBLY BIOSCIENCES INC (US) 2021-07-07 — — EP disclosed
EP-3589630-B1 CYCLIC SULFAMIDE COMPOUNDS AND METHODS OF USING SAME ASSEMBLY BIOSCIENCES INC (US) 2021-07-07 — — EP disclosed
US-20200157070-A1 CYCLIC SULFAMIDE COMPOUNDS AND METHODS OF USING SAME ASSEMBLY BIOSCIENCES INC (US) 2020-05-21 — — US disclosed
CN-110621672-A Cyclic sulfonamide compounds and methods of use thereof 组装生物科学股份有限公司 2019-12-27 — — CN disclosed
WO-2018160878-A1 CYCLIC SULFAMIDE COMPOUNDS AND METHODS OF USING SAME ASSEMBLY BIOSCIENCES, INC. (US) 2018-09-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230012463-A1 CYCLIC SULFAMIDE COMPOUNDS AND METHODS OF USING SAME HCCS, HAVCR2, SLC10A1 MEN1 3885/4885KMT2A 2749/4885MAPT 4637/4885
US-11078170-B2 Cyclic sulfamide compounds and methods of using same HCCS, HAVCR2, SLC10A1 MEN1 3885/4885KMT2A 2749/4885MAPT 4637/4885
US-20200157070-A1 CYCLIC SULFAMIDE COMPOUNDS AND METHODS OF USING SAME HCCS, HAVCR2, SLC10A1 MEN1 3885/4885KMT2A 2749/4885MAPT 4637/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.