Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 20/20 | 0.52 |
| ▸ | WDR77 | Q9BQA1 | 20/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20488476 | 1.00 | PRMT5 (0.52) | PRMT5WDR77 | |
| SCHEMBL21359308 | 0.92 | PRMT5 (0.43) | PRMT5WDR77 | |
| SCHEMBL29383366 | 0.92 | PRMT5 (0.43) | PRMT5WDR77 | |
| SCHEMBL20488479 | 0.92 | PRMT5 (0.43) | PRMT5WDR77 | |
| SCHEMBL20488478 | 0.92 | PRMT5 (0.43) | PRMT5WDR77 | |
| SCHEMBL20488142 | 0.86 | PRMT5 (0.58) | PRMT5WDR77 | |
| SCHEMBL30207994 | 0.86 | PRMT5 (0.45) | PRMT5WDR77 | |
| SCHEMBL19667408 | 0.86 | PRMT5 (0.45) | PRMT5WDR77 | |
| SCHEMBL30208000 | 0.86 | PRMT5 (0.45) | PRMT5WDR77 | |
| SCHEMBL20489002 | 0.84 | PRMT5 (0.62) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018160824-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2018-09-07 | — | — | WO | disclosed |