Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 3/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.57 |
| ▸ | CNR2 | P34972 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2847510 | 0.92 | HDAC4 (0.64) | HDAC4HDAC7HDAC5HDAC3HDAC1 | |
| SCHEMBL8112770 | 0.90 | HDAC4 (0.54) | HDAC4HDAC7HDAC5HDAC3HDAC1 | |
| SCHEMBL20490576 | 0.88 | HDAC4 (0.53) | HDAC4HDAC7HDAC5HDAC3HDAC1 | |
| SCHEMBL4541569 | 0.87 | HDAC3 (0.51) | HDAC4HDAC7HDAC5HDAC3HDAC1 | |
| SCHEMBL2839582 | 0.85 | HDAC3 (0.55) | HDAC4HDAC7HDAC5HDAC3HDAC1 | |
| SCHEMBL20490527 | 0.85 | HDAC4 (0.49) | HDAC4HDAC7HDAC5HDAC3HDAC1 | |
| SCHEMBL20490324 | 0.81 | HDAC4 (0.60) | HDAC4HDAC7HDAC5HDAC3HDAC1 | |
| SCHEMBL4524907 | 0.80 | HDAC4 (0.55) | HDAC4HDAC7HDAC5HDAC3HDAC1 | |
| SCHEMBL2839908 | 0.78 | HDAC4 (0.57) | HDAC4HDAC7HDAC5HDAC3HDAC1 | |
| SCHEMBL2842515 | 0.78 | HDAC4 (0.70) | HDAC4HDAC7HDAC5HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139850-B1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2018-09-12 | — | — | EP | claimed |
| EP-2139850-B1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2018-09-12 | — | — | EP | disclosed |