Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 7/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20490507 | 0.88 | HDAC4 (0.54) | HDAC4HDAC7HDAC5HDAC3HDAC1 | |
| SCHEMBL2842461 | 0.78 | HDAC4 (0.81) | HDAC4HDAC7HDAC5HDAC3HDAC1 | |
| SCHEMBL20490457 | 0.78 | HDAC4 (0.64) | HDAC4HDAC7HDAC5HDAC3HDAC1 | |
| SCHEMBL20490215 | 0.78 | HDAC4 (0.64) | HDAC4HDAC7HDAC5HDAC3HDAC1 | |
| SCHEMBL11840187 | 0.77 | ESR2 (0.56) | ESR2MMEPTPN5FFAR1AKR1B1 | |
| SCHEMBL2839032 | 0.76 | HDAC4 (1.00) | HDAC4HDAC7HDAC5HDAC3HDAC1 | |
| SCHEMBL2839404 | 0.76 | HDAC4 (0.60) | HDAC4HDAC7HDAC5HDAC3HDAC1 | |
| SCHEMBL11795905 | 0.75 | ESR2 (0.54) | ESR2MMEPTPN5FFAR1AKR1B1 | |
| SCHEMBL20490371 | 0.75 | HDAC4 (0.58) | HDAC4HDAC7HDAC5HDAC3HDAC1 | |
| SCHEMBL2843752 | 0.75 | FFAR1 (0.57) | HDAC4HDAC7HDAC5HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139850-B1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2018-09-12 | — | — | EP | claimed |
| EP-2139850-B1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2018-09-12 | — | — | EP | disclosed |